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CAREER: Molecular Assemblies of Multidomain Signaling Protein on Membrane Surface

Abstract: Many proteins that carry out critical life processes are modular in structure, i.e., composed of multiple independent domains, and the intra- and intermolecular interactions among these domains determines function. Often, changes in these structural organization that leads to activation occurs at the cellular membrane, which remains experimentally inaccessible. This project will develop a technology that can elucidate the molecular interactions on membrane surfaces using Bruton’s tyrosine kinase (Btk) as a model system. The project will develop experimental tools for elucidating structural details for biomolecular assemblies on membranes, as well as the understanding of Btk and other similar multidomain proteins. Integrated with this research strategy, the education plan seeks to instill the concepts of microscopy and single-molecule imaging in the public, in collaboration with the Colorado State University Spur Campus. The plan is based on the idea that aesthetic appreciation for scientific imageries can facilitate the understanding and affinity towards science. Artistic actives that combine natural concepts will be incorporated into creative activities in which artistic techniques illustrate the concepts.

Status: Current

PI: Jean Chung, Ph.D.

PI Institution: Colorado State University

PI College: College of Natural Sciences

Source of Funding: NSF

Funding Program: CAREER

Award Amount: $786,920

Start Date: 01/01/2023

End Date: 12/31/2027

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